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A rapid escalation is associated with low blood sugar levels and severe GI side effects such as severe abdominal pain, nausea, vomiting, and inflammation of the pancreas (pancreatitis)
If you dont have enough insulin, your blood sugar increases, leading to diabetes
Maybe an interesting read also in this context
Brain Behav Immunity
After four weeks, the dose typically increases to 0.5mg per week for another four weeks, then continues titrating upward
A 5-days-on / 2-off variant (dosing MondayFriday, resting the weekend) also appears in the research framing for those studying receptor-sensitivity preservation
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