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The MTHFR gene (methylenetetrahydrofolate reductase) is responsible for converting folate into its active form, methylfolate

Alterations in iron levels may therefore induce abnormal microglial activation, increasing hypersensitivity and promoting chronic neuroinflammation

Both experimental and review articles addressing peptides efficacy and potential in systemic and ocular disease were included

[2] Glutathione deficiency and mitochondrial dysfunction in aging Sekhar RV, et al

By using the passive and/or active strategies for BBB regulation and crossing in a controlled and non-invasive manner, various drug delivery systems are engineered to facilitate the brain-targeted delivery of specific therapeutics including small-molecule drugs, proteins, genes, and other biopharmaceutics

[5] Jzwiak, M., Bauer, M., Kamysz, W., & Kleczkowska, P