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Interferon- mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes

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BPC-157 promotes collagen synthesis through EGR1 transcription factor activation: EGR1 binds GC-rich promoter elements in collagen (COL1A1, COL3A1), fibronectin, and VEGF genes, driving coordinate upregulation of repair-phase ECM components

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For example, METTL3 methylates NLRP3 mRNA in diabetes-related periodontitis through an IGF2BP3-dependent pathway