Fortunately, these symptoms often subside as your body adjusts
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Observed RHR Increases in Clinical Data: + Liraglutide (1.8 mg daily): +610 bpm + Semaglutide (1.02.4 mg weekly): +24 bpm + Tirzepatide (515 mg weekly): +1.53.5 bpm + Exenatide (5-10 g Twice daily): +23 bpm A meta-analysis of over 60 randomized clinical trials found the mean RHR increase with GLP-1RAs to be 2.11 bpm (95% CI: 1.682.54)
Starting conversations with your provider should include discussion of your weight-loss history, metabolic markers, family history of obesity or diabetes, and any prior experience with medications that affect appetite or mood
The best time to start your muscle preservation protocol was the day you started GLP-1 medications
Whether one or the other works for you depends on whether you can afford the medication, take it consistently, and change your lifestyle for long-term use