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Natural bioactive compounds synergize with 5-ASA to potently suppress these acute inflammatory responses through multiple, complementary mechanisms ( + /CD8 + T-cell balance, which is associated with significant reductions in the Baron endoscopic score and disease activity index (DAI) ( Concurrently, these compounds combat oxidative stress, a key driver of tissue damage in acute inflammation ( Following the suppression of acute inflammation, successful UC therapy necessitates active promotion of mucosal healing and restoration of intestinal homeostasis ( Natural components also modulate the gut microbiota and metabolism microenvironment

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While these compounded versions are not FDA-approved, they offer a vital alternative for many people, especially during national shortages of branded products