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In a Phase 2 randomised controlled trial published in the New England Journal of Medicine in 2023 (Jastreboff et al., NEJM 2023), adults with obesity (without type 2 diabetes) who received the highest dose of retatrutide (12 mg weekly) achieved a mean body weight reduction of approximately 24% over 48 weeks

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During sustained low to moderate exercise, fatty acid oxidation increases to become the predominant energy source to muscles [17]

In 2016, another balanced dual receptor agonist demonstrated pronounced effect on bodyweight and glucose control, together with reducing hepatic fat content in rodents and non-human primates (73)