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GLP-1 receptor agonists reduce appetite and body weight
Participants also recorded reductions in waist circumference (average 7.1cm loss on 6mg, 8.2cm on 12mg, 10cm on 36mg, compared with 3.1cm loss on placebo), blood pressure (estimated -4.2 and -1mm HG difference between placebo and orforglipron in systolic and diatolic blood pressure, respectively) and cholesterol (-2.1% difference between placebo and orforglipron)
But there are rules, and breaking them can cause side effects or reduced efficacy
review tolerability, hydration, sick-day understanding, weight trajectory)
Stay consistent with nutrition to prevent blood sugar dips