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Based on what patients report

A 2025 systematic review and meta-analysis in JAMA Psychiatry found no overall increase in psychiatric side effects, including depression, with GLP-1 medications, but individual responses still vary, which is why we monitor rather than assume

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Kidney Problems: NSAIDs can reduce blood flow to the kidneys, which might impair their function

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For weight management, GLP-1 agonists act on appetite centres in the brain , particularly the hypothalamus, reducing hunger and food intake