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Research has shown it can modulate glutamate activity, the brains primary excitatory neurotransmitter that opposes GABA

However, tapering is not necessary for everyone

In addition, if someone already has a condition that affects their muscles or nerves, such as a previous injury or a disease like peripheral neuropathy, they may be at higher risk of developing leg cramps when using semaglutide

If youre interested in exploring whether Ozempic or another medication can help you reach your weight loss goals, schedule a consultation with us today

Retrieved April 19, 2026

No, sore throat is not a documented side effect of semaglutide in clinical trials