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Steric hindrance from the increased side-chain volume of E14 Cagri and R17 Cagri promotes a shift of the -helix of Cagri away from ECL2 and a slight expansion of the peptide binding pocket at the extracellular side of the CTR TM domain, relative to those observed with rAmy/San385-bound AMYR complexes
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Type 2 diabetes in adults: management (NG28) Blood glucose management chapter
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Alternatively, the loss of these circulating adhesion molecules could also reflect the overall loss of plasma protein if it is due to leakage out of the vascular compartment
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