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Intracellularly, 5-methylTHF functions as a methyl donor for homocysteine (hcy) remethylation, a reaction catalyzed by the methionine synthase (MTR) enzyme that transfers a methyl group from 5-methylTHF to hcy, forming tetrahydrofolate (THF) and methionine

In the MASLD (metabolic dysfunction-associated steatotic liver disease) substudy, participants on the 12 mg dose achieved greater than 85% liver fat normalization

This makes visceral fat reduction a key therapeutic target in managing obesity-related conditions, which is where newer pharmacological interventions such as GLP-1 receptor agonists have shown promise

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When mitochondria do not work well, cells get stressed

Individual results may vary, and long-term effects are still under investigation