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People with lower CYP1A2 activity may generate reactive aflatoxin metabolites more slowly (could be a good thing), but they can still be vulnerable if downstream conjugation pathways (GSTs, UGTs) are also compromised.[ref] Related article: CYP1A2 Gene: Fast or Slow Caffeine Metabolizer and More CYP3A4 and aflatoxin G1 / other mycotoxins: CYP3A4 is involved in the metabolism of aflatoxin G1 and many other compounds, including medications
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Furthermore, a combination of our methods with targeted sample preparation and enrichment tools (e.g., immunoaffinity) could be applied to analyze the NAPQI binding affinity of GST and various proteins of interest in the future
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