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These functions of GLP-1R in the CM model is mediated by its downstream PI3K/Akt pathway (Fig
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T.GuoH.et al
Pathways enriched for DEGs selected from Gipr fl/fl vehicle versus Gipr Syn/ vehicle, as well as Gipr fl/fl vehicle versus Gipr fl/fl mGIPR-Ab/P1 comparisons, demonstrated that reduction of CNS GIPR function through either pharmacological or genetic intervention led to downregulation within adipose tissue of key canonical genes within these pathways (Fig
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