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The activity of these enzymes is enhanced by a variety of chemicals, including caffeine[40, 41] and anticonvulsant drugs[42], and it is well known that co-ingestion of these drugs with APAP can greatly enhance the toxicity of APAP

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Although ACC2 does oligomerization similar to that of ACC1, it does not appear to occur to the extent of that of ACC presumably due to its mitochondrial association