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Several HSP90 inhibitors, including 17-DMAG (alvespimycin), 17-AAG (tanespimycin), ganetespib and geldanamycin, exhibit senolytic effects across multiple senescent cell types through distinct, cell-type-specific mechanisms
While its naturally present in every cell, its levels decline due to stress, ageing, pollution, and UV exposure
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No published monotherapy pharmacokinetic dataset exists
Thymosin 4 up-regulation of microRNA-146a promotes oligodendrocyte differentiation and suppression of the Toll-like proinflammatory pathway
Polyamine metabolite spermidine rejuvenates oocyte quality by enhancing mitophagy during female reproductive aging
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