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A large number of GLP-1Rpositive cells were also detected throughout various hypothalamic nuclei, mainly in the PVN, dorsomedial hypothalamic nucleus (DMH), and Arc, and among scattered neurons in the lateral hypothalamus
H.KozloffK
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Earlier STEP trials reinforced these findings, showing average weight loss near 15% over 68 weeks when semaglutide was paired with lifestyle guidance
PubMed Leyden J et al
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