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The most common side effects are nausea, vomiting, and diarrhea
The apparent permeability coefficients (P app ) were calculated as described previously [40] with the following equation: where [C] A is the concentration difference of in the acceptor compartment at 24 h, [C] D is the concentration in the donor compartment at 0 h, V A is the volume of the acceptor compartment (0.9 ml), and A is the surface area available for permeability (0.33 cm 2 )
This can occur due to loss of appetite, digestive issues, and muscle weakness, which are common side effects of B12 deficiency
However, we found that, while access-related issues were a leading cause of early discontinuation, subsequent switches were frequently attributed to lack of efficacy, injection burden or AEs
75 For example, in prostate cancer, loss of the histone methyltransferase KMT2C represses ASPP2 via impaired enhancer activity
