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Retrieved from Tchang, B

Had to take more than the recommended dosage

Peptides exist in a grayer area

Controlled human intervention studies demonstrate that consumption of whole, dried Lentinula edodes (510 g/day) enhances innate and mucosal immune function by increasing -T and NK-T cell proliferation and activation, elevating salivary sIgA, and modulating cytokine profiles toward a less inflammatory state, supporting shiitake mushrooms as a functional food with immunomodulatory potential [36]

This is qualitatively different from what anti-inflammatory medications produce, because the tissue itself is changing rather than just the symptom signal being blocked