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Making drugs that stick around Despite all their activity in the body and brain, naturally occurring GLP-1 hormones dont make good drugs
Semaglutide consistently improved all outcomes across obesity categories ( P value for treatment effects BMI interactions = not significant for all)
Still, her big comeback to the court next week is great news for the pro-peptide guys, who are keen to show that peptides are much more than drugs to treat chronic diseases like obesity and type 2 diabetes
These include Alzheimers Disease, Infertility, Depression, and Diabetes
Competing interests VRA has served as a consultant for Applied Therapeutics, Fractyl Health, Novo Nordisk, Pfizer, and Sanofi
The EMPA-REG OUTCOMES trial showed that empagliflozin, a SGLT-2i, markedly reduced the risk for HF hospitalization relative to the placebo ( HR = 0.65, 95% CI 0.500.85, P = 0.002) [96]
