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& Owsley, C

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A recent review has connected various clinical events to redox factors and OS in cardiovascular pathophysiology, providing evidence for new pharmacological therapies such as OFAs, non-selective beta-blockers, and microRNAs (Faras et al., 2017)

Ultrathin sections (80 nm thick) were cut with an ultramicrotome (Leica, EMUC6, Germany), and then stained with uranyl acetate and lead citrate and finally examined by a Tecnai G 2 Spirit TWIN transmission electron microscope (FEI, Hillsboro, OR, USA)

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Following FOXO4 displacement, the released p53 undergoes nuclear export and mitochondrial translocation, activating the intrinsic apoptosis pathway via BAX upregulation and BCL-2 downregulation, culminating in caspase-3 cleavage and apoptotic cell death