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For the GSSCys assays, either GSH was varied between 50 M and 2.0 mM at fixed GSSCys concentrations (25, 50, 100 and 150 M) or GSSCys was varied between 25 and 200 M at fixed concentrations of GSH (0.05, 0.1, 0.2, 0.3 and 1.0 mM for ScGrx7 or 0.3, 0.5, 1.0 and 2.0 mM for PfGrx)
Among these, Metformin combined with Rosiglitazone maleate (KEGG ID: D10244) and Metformin combined with Pioglitazone hydrochloride (KEGG ID: D09744) stand out, both exhibiting an impact score of 233.754, the highest among Metformin combination therapies
Presented for research literature review only Machon O et al
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