If you are currently experiencing postpartum depression or anxiety that is not yet stabilized with treatment, adding a new medication that affects appetite, energy, and gastrointestinal function can complicate the clinical picture
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Many research studies have shown that MTX and its byproducts can lead to inflammatory responses, oxidative stress, fibrosis, and cell death in liver cells (Chauhan et al
This they investigated by testing the peptides in plasma collected from six healthy individuals both when they fasted and had a mixed meal (rskov, Holst
Its also a personal decision based on your own preferences
Theres a lot of potential for both in the right context