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Furthermore, semaglutide has demonstrated benefits in managing various other health conditions such as cardiovascular factors, alcohol use, smoking and depression, many of which are also linked to AD risk. Building on preclinical evidence that suggests semaglutide (Novo Nordisk) protects against neurodegeneration and neuroinflammation consistent with AD, Xu and colleagues assessed its potential for delaying or preventing AD in a real-world setting

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Likewise, for assessing the change in relative IBA1 or GFAP in the hippocampus or entire brain following semaglutide treatment, a linear model was constructed for each protein and each brain region using the protein percentage as dependent variable and treatment (veh-LPS and sema-LPS) and time (2d and 11d after the last LPS injection) as independent variables with interaction effects

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