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It reduces lipogenesis, the process of creating new fat

Common gastrointestinal effects (Phase 2 NEJM) Retatrutide GI side effects at 12 mg in the Phase 2 NEJM trial Effect Nausea Rate at 12 mg Up to 25% Effect Diarrhea Rate at 12 mg Up to 23% Effect Vomiting Rate at 12 mg Up to 26% Effect Constipation Rate at 12 mg Up to 16% GI symptoms were most common during dose escalation and were usually mild to moderate

This suggests T4 might play a role in disease pathogenesis or tissue repair

Examples include: Metformin , which improves insulin sensitivity Jardiance , which promotes glucose excretion through urine Glipizide , which stimulates insulin release These medications work through different metabolic pathways and may be prescribed alone or in combination depending on patient needs

One reason IV therapy has gained attention is its method of delivery

Br J Nutr (2011) 105:1798807