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Moreover, intracellular levels of glucose-6-phosphate (G6P) were not reduced following melatonin treatment ( Figure 5H ), whereas fructose-6-phosphate (F6P) was markedly decreased ( Figure 5I )

Another study suggested that oxidative stress-induced 4-hydroxy-2-nonenal (HNE) triggers mitochondrial translocation of AIFM2, promoting apoptosis in cardiac tissues of both mice and humans 40

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August 2007