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Current Alternatives While waiting for Retatrutide approval, Canadian patients with prescriptions can access: Wegovy (semaglutide): Health Canada approved, available through pharmacies Saxenda (liraglutide): Health Canada approved, daily injection option Zepbound (tirzepatide) is FDA approved but Health Canada approval status should be verified with current regulatory updates

Using the estimated coefficients of the baseline characteristics that remained in the CV risk prediction model, a risk score could then be calculated for LEADER and extrapolated to other trials that measured the same baseline characteristics

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But as with any therapy that influences appetite, metabolism, and hormones, there are complex downstream effectsand one thats less commonly discussed is a change in libido

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Research demonstrates that IGF-1 LR3 activates the same downstream pathways as native IGF-1, primarily the PI3K/Akt/mTOR and Ras/MAPK/ERK cascades, but with greater potency due to its prolonged receptor availability