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In addition, lifestyle optimizers people who value structure in their nutrition, activity, and supplementation are finding appeal in solutions that integrate seamlessly into existing habits

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SURMOUNT-1 and STEP-1: Obesity-Specific Trials SURMOUNT-1 (Tirzepatide for Obesity, NEJM 2022): At the maximum 15 mg dose, participants without diabetes lost an average of 22.5% of their body weight over 72 weeks approximately 51 lbs for a 225-lb person

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In some cases a B12 deficiency can affect the optic nerve, leading to disturbances or changes in vision

17,42,166,201 However, clinical studies of SGLT2 inhibitors have been limited to patients with diabetes and NAFLD or NASH, necessitating large, high-quality, randomized controlled trials to explore their effectiveness in all patients with NAFLD or NASH