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Melanocortin receptors , including MC1R , are expressed on peripheral immune cells including macrophages, neutrophils, and lymphocytes, and research has examined MT-1s systemic anti-inflammatory effects in inflammatory disease models beyond skin biology

This aligns with what the best research shows

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Short-term L-citrulline supplementation does not affect blood pressure, pulse wave reflection, or arterial stiffness at rest and during isometric exercise in older males

The University of Hong Kong

The real challenge is maintaining the health benefits for years to come