In the absence of apoptotic stimuli, anti-apoptotic proteins Bcl-2, Bcl-xl, and MCL1 form heterodimers with pro-apoptotic proteins Bax or Bak, inhibiting the pro-apoptotic activity of Bax/Bak and maintaining the integrity of the mitochondrial outer membrane, thus blocking mitochondrial apoptosis (Desagher and Martinou, 2000)
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