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Patients with PD primarily exhibit a significant loss of insulin receptor mRNA in the substantia nigra pars compacta, increased insulin IR, and reduced activation of molecules such as insulin receptor substrate 1 (IRS1) and protein kinase B (Akt) within the insulin metabolic pathway (24)

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Cardiovascular protection through potential impacts on blood vessels and heart tissue

Plast Reconstr Surg Glob Open

Some data suggest that baseline microbial patterns may affect weight loss and glycemic response, although this remains an active area of research