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Semaglutide combined with lifestyle significantly reduced body weight, and this weight loss primarily resulted from the decrease in fat mass, which is consistent with the core conclusions of current studies on GLP-1 RAs [8,19-22]

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Its treatment was reported to increase the levels of GSH and the activities of GPX and GST, along with a decrease in cardiac lipid peroxide production in a rat model of myocardial injury caused by diazinon (a pesticide) [180]

Both build upon the established foundation of GLP-1 receptor activation but expand the mechanism in distinct ways