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Weston SB, Zhou S, Weatherby RP, Robson SJ
We next used a panel of tumor cell lines from different types of cancers with relatively high ERK5 mRNA or protein levels (based on the DepMap resource and protein level verification by us) [45, 46], namely A427 (lung adenocarcinoma), Huh-7 (hepatocellular carcinoma), JHH-7 (hepatocellular carcinoma) and MDA-MB-231 (breast adenocarcinoma) cells
Notably, TNF- plays a key inhibitory role in regulating cholesterol synthesis
Rolando Grave de Peralta Menendez and Sara Gonzalez Andino developed the LAURA source estimation methods applied here, and Christoph Michel provided additional analysis software
Understanding Insulin-like Growth Factor-1 Insulin-like growth factor-1 (IGF-1), formerly known as somatomedin or somatomedin C, has a single chain 70-amino acid polypeptide cross-linked by 3 disulfide bridges. Although IGF-1 provides several benefits similar to insulin such as lower blood sugar levels, the key difference is that insulin mediates mainly a metabolic response, whereas IGF-1 mediates growth-promoting effects (Source)
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