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Rapid ligand-receptor binding and efficient uptake by target cells are critical for receptor-targeted delivery systems to avoid in vivo clearance

Supporting a dominant role for diet composition in establishing the Firmicutes : Bacteroidetes ratio, previous work has shown that mice maintained on a high-fat diet had a similar cecal Firmicutes : Bacteroidetes ratio to those maintained on a high-carbohydrate diet 77

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References: Hira, T., Trakooncharoenvit, A., Taguchi, H., & Hara, H

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NAC's parent-molecule oral bioavailability is estimated at approximately 4-16% due to first-pass hepatic metabolism