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Focus on building sustainable habits during this phase rather than maximizing immediate weight loss
In phase 2 trials, people lost anywhere from 7% to 24% of their body weight in 48 weeks, depending on the dose
One seen as easier: GLP-1 medications
Behavioral strategies like consistent meal timing, protein intake optimization, and regular movement become the foundation of long-term weight maintenance
Insulin and glucagon were determined by radioimmunoassay (Millipore and Oxford Biosystem, respectively) according to the manufacturers instructions
For the narrower MACE-3 composite of cardiovascular death, myocardial infarction, or stroke, 27 events occurred among participants receiving retatrutide compared with 23 in the placebo group, resulting in a hazard ratio of 1.12 (95% CI: 0.64-1.96)
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