While not strictly "required," Vitamin C is a powerful synergistic partner for both
If the liver is bogged down by toxins and lacks the glutathione it needs for detoxification, it can lead to an imbalance
Sources MHRA smashes major illicit weight loss medicine production facility in record seizure, MHRA [accessed 29 October 2025] Mounjaro KwikPen 2.5mg solution for injection in pre-filled pen, emc [accessed 29 October 2025] Once-Weekly Semaglutide in Adults with Overweight or Obesity, The New England Journal of Medicine (NEJM) [accessed 29 October 2025] Tirzepatide Once Weekly for the Treatment of Obesity, NEJM [accessed 29 October 2025] TripleHormone-Receptor Agonist Retatrutide for Obesity A Phase 2 Trial, NEJM[accessed 29 October 2025] Patient Reviews Related Weight Loss Treatments Further Reading on Weight Loss Do Appetite Suppressants Work
3 To bolster supply chain security, the agency maintains a green list import alert (66-80) to prevent GLP-1 active pharmaceutical ingredients (APIs) with quality concerns from entering the U.S., while still allowing legal importation from compliant manufacturers
"Health Canada won't approve it as a drug, but it slips through as a compounded natural health product, where the federal safety check basically doesn't happen." Health Canada considers NHP compounding within a practitioner-patient relationship distinct from manufacturing and not subject to the same regulatory oversight
Activated microglia release IL-1, which stimulates astrocytes to secrete VEGF and proinflammatory chemokines like CXCL2, CCL2, and CCL20, further exacerbating BBB dysfunction [240]