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The peptides absorb well through subcutaneous tissue, and this method is easier and less painful than intramuscular injection
Clinicians use that context to decide whether a shifted value needs follow-up, represents an expected therapeutic response, or signals an adverse event
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b ) Placebo-adjusted weight change with placebo-adjusted HbA1c change
The peptides well-characterized in vitro effects and favorable preliminary safety profile position it well for translational investigationif undertaken with pharmaceutical-grade materials and rigorous methodology
It acts directly on neighboring -cells to inhibit the secretion of glucagon and can also indirectly influence -cells by inhibiting the secretion of other hormones.243 In the local islet environment, a high concentration of somatostatin creates an inhibitory milieu, further reducing the activity of -cells and the secretion of glucagon.244 Additionally, somatostatin can inhibit gastrointestinal activity, reducing the secretion of pancreatic enzymes and gastric acid, thereby indirectly decreasing the demand for glucagon.245,246 Hence, GLP-1 activates -cells and promotes somatostatin secretion, forming a multi-layered inhibitory mechanism that effectively reduces glucagon secretion
