Glucose-Dependent: The response only occurs after a meal when blood sugar levels rise to reduce the chance of hypoglycemia occurring
Note: most injectable protocols are extrapolated from topical human trials rather than injectable-specific RCTs
Grote, C
(NEJM, 2023) showed approximately 24% mean weight reduction with Retatrutide at 12 mg at 48 weeks, while Semaglutide demonstrated approximately 15% at 2.4 mg weekly in the STEP trials again, these are cross-trial figures drawn from studies with different designs and populations, and should be treated as indirect
While this guidance was directed primarily at hormone therapy, its underlying principle, preferring approved therapies when available, applies to the broader compounded peptide space
PeterMDs semaglutide program is available in approximately 46 states plus Washington, DC, excluding Alabama, Idaho, Alaska, and Hawaii